CHANGE IN FIBRINOLYTIC-ACTIVITY AS A PARAMETER FOR ASSESSING LOCAL MECHANICAL STIMULATION DURING PHYSICAL EXERCISE

The influences of mechanical force during physical exercise on blood c oagulation and fibrinolysis were investigated and the effects of sport s equipment, especially shoes were also examined. As an experimental m odel, local mechanical vibration was applied to the palm of the hand. General coagulation parameters did not change, but fibrinolytic activi ty was elevated due to the tissue plasminogen activator (t-PA) release d from vascular endothelial cells stimulated by vibration. The influen ce of mechanical stimulation by repeated side-jumping with bare feet w as examined on the sole of the foot. As with t-PA, the von Willbrand F actor antigen (vWF:Ag) derived from vascular endothelial cells also te nded to increase, but not as much as when wearing sports shoes. Sports shoes protected the blood vessels of the feet from damage by mechanic al force during physical exercise. Changes in fibrinolytic activity an d t-PA could be useful for assessing local mechanical stimulation duri ng physical exercise and also as indexes for the development of new sp orts equipment and its improvement.