RELATIONSHIP OF PANIC, ANTICIPATORY ANXIETY, AGORAPHOBIA AND GLOBAL IMPROVEMENT IN PANIC DISORDER WITH AGORAPHOBIA TREATED WITH ALPRAZOLAM AND EXPOSURE

In a controlled trial of alprazolam and exposure in 154 patients with panic disorder with agoraphobia, relations between panic, anticipatory anxiety, and phobic avoidance were examined. The three symptoms were independent of one another at baseline and improved largely independen tly during treatment; only early improvement in avoidance predicted gl obal improvement after treatment. Global improvement was more related to reduction of avoidance than a decrease in panics. Panic was not a v aluable outcome measure in panic disorder with agoraphobia.