SYNTHESIS AND BIOLOGIC EVALUATION OF 8-SUBSTITUTED DERIVATIVES OF NEBULARINE (9-BETA-D-RIBOFURANOSYLPURINE)

Authors
SECRIST JA SHORTNACYFOWLER A BENNETT LL MONTGOMERY JA
Citation
Ja. Secrist et al., SYNTHESIS AND BIOLOGIC EVALUATION OF 8-SUBSTITUTED DERIVATIVES OF NEBULARINE (9-BETA-D-RIBOFURANOSYLPURINE), Nucleosides & nucleotides, 13(5), 1994, pp. 1017-1029
Citations number
20
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
5
Year of publication
1994
Pages
1017 - 1029
Database
ISI
SICI code
0732-8311(1994)13:5<1017:SABEO8>2.0.ZU;2-6
Abstract
A series of 8-substituted purine ribonucleosides were prepared from 2' ,3',5'-tri-O-acetyl-8-bromoadenosine and evaluated for cytotoxicity an d antiviral activity. Four of these nucleosides (6b-9b) were significa ntly toxic to both HEp-2 and L1210 cells in culture but the most cytot oxic one (9b) was inactive against the P388 leukemia in mice. None of these nucleosides showed significant antiviral activity against Herpes Simplex 1 or 2, vaccinia, or influenza A.