AN ALTERNATIVE ROUTE FOR PREPARATION OF ALPHA-METHYLPHOSPHONYL-BETA,GAMMA-DIPHOSPHATES OF THYMIDINE DERIVATIVES

Authors
ARZUMANOV AA DYATKINA NB
Citation
Aa. Arzumanov et Nb. Dyatkina, AN ALTERNATIVE ROUTE FOR PREPARATION OF ALPHA-METHYLPHOSPHONYL-BETA,GAMMA-DIPHOSPHATES OF THYMIDINE DERIVATIVES, Nucleosides & nucleotides, 13(5), 1994, pp. 1031-1037
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
5
Year of publication
1994
Pages
1031 - 1037
Database
ISI
SICI code
0732-8311(1994)13:5<1031:AARFPO>2.0.ZU;2-U
Abstract
An alternative ''one pot'' synthesis of alpha-methylphosphonyl-beta,ga mma-diphosphates of thymidine and 3'-azidothymidine is proposed. p-Tol uene-sulphonic acid was used as desililating agent for triphosphate an alogues.