SYNTHESIS OF ETA-D-RIBOFURANOSYLAMINO)PYRIMIDO[5,4-D]PYRIMIDINE (DFARPP) - STABILITY AND CELLULAR CYTOTOXICITY

Authors
MABRY TE JONES CD CHOU TS COLACINO JM GRINDEY GB WORZALLA JF PEARCE HL
Citation
Te. Mabry et al., SYNTHESIS OF ETA-D-RIBOFURANOSYLAMINO)PYRIMIDO[5,4-D]PYRIMIDINE (DFARPP) - STABILITY AND CELLULAR CYTOTOXICITY, Nucleosides & nucleotides, 13(5), 1994, pp. 1125-1133
Citations number
21
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
5
Year of publication
1994
Pages
1125 - 1133
Database
ISI
SICI code
0732-8311(1994)13:5<1125:SOE(>2.0.ZU;2-F
Abstract
The synthesis of beta-dFARPP was accomplished by Mitsunobu coupling of 6-cyanopurine with 2-deoxy-2,2-difluororibose followed by purine ring -expansion under the action of methanolic ammonia. The title compound inhibited the growth of proliferating human leukemic CCRF-CEM cells at 6.1 mu g/ml but had no effect on plaque formation by a variety of DNA and RNA viruses.