T. Nakada et al., HIGH-LEVEL OF NONCOLLAGENOUS PROTEIN OF SPERMATIC VEIN IN PATIENTS WITH VARICOCELE, The Journal of urology, 151(6), 1994, pp. 1539-1542
Spermatic vein specimens were removed from 46 patients with varicocele
who underwent high ligation of the left spermatic vein and 11 men wit
h renal cancer who underwent radical nephrectomy. Semen analysis was p
erformed preoperatively and after 3 months, and the contents of noncol
lagenous protein, collagen and elastin in the spermatic vein were dete
rmined. The noncollagenous protein contents in the spermatic vein were
greater in patients with grades 2 and 3 varicocele than in those with
renal cancer (p <0.001) and grade 1 varicocele (p <0.01), respectivel
y. Similar results, to a lesser extent, were also obtained for the con
tents of collagen. The content of elastin in each group was identical.
Noncollagenous protein content correlated inversely with sperm count
and sperm motility in all varicocele groups, as did collagen content i
n patients with grades 2 and 3 varicocele. These results indicate that
there is an association between a large amount of noncollagenous prot
ein and collagen in the spermatic vein and deterioration of the spermi
ogram in patients with grades 2 and 3 varicocele.