MANAGEMENT OF WOMEN MILD AND MODERATE CERVICAL DYSKARYOSIS

Objective-To compare the outcomes in women with mild and moderate dysk aryosis after increasing periods of surveillance and thereby to define a rational protocol for managing such women. Design-Prospective study with randomisation of women to one of four treatment groups, each wit h a different period of surveillance; one group in which the women wer e given immediate treatment and three other groups in which the women were under surveillance for six, 12, and 24 months. Setting-A dedicate d colposcopy clinic in Aberdeen, Scotland. Subjects-902 women who pres ented with a mildly or moderately dyskaryotic smear for the first time . Interventions-Cytological and colposcopic examinations at intervals of six months until the allocated period of surveillance was completed , at which time biopsy was performed. Women with severe dyskaryosis we re withdrawn from surveillance and a biopsy was performed. Main outcom e measures-The histological findings after punch biopsy or large loop excision of the transformation zone, and the trends in cytological app earances of serial cervical smears. Results-793 women completed the st udy. In all, 769 women had an adequate final smear, of which 197 were normal cytologically, 328 were still mildly or moderately dyskaryotic, and 244 were severely dyskaryotic. Seventeen of the 67 (25%) women wi th one repeat smear showing non-dyskaryosis had cervical intraepitheli al neoplasia grade III compared with only one of the 31 (3%) women wit h no dyskaryosis in four repeat cervical smears (P < 0.0001). None of the women had invasive cancer. Of 158 women whose index smear showed m ild dyskaryosis and who were allocated to the group under surveillance for two years, only 40 had not defaulted or still had dyskaryotic sme ars by the end of the two years. Conclusion-Cytological surveillance, although safe, is not an efficient strategy for managing women with mi ldly abnormal smears. Women with any degree of dyskaryosis in a smear should be referred for colposcopy.