SUPPRESSION OF HYPERALGESIA IN STREPTOZOTOCIN-INDUCED DIABETIC MICE BY A LIPOPOLYSACCHARIDE FROM PANTOEA-AGGLOMERANS

The ability of a lipopolysaccharide from Pantoea agglomerans (LPSp) to relieve hyperalgesia was examined by observing its inhibition of the decrease in the threshold for nociceptive perception, as determined by the tail-pinch test, in streptozotocin-induced diabetic mice. Subcuta neous injection of LPSp suppressed hyperalgesia in streptozotocin-indu ced diabetic mice and also exerted a therapeutic effect on hyperalgesi a in these animals. The present data suggest that LPSp may be effectiv e in relieving the pain associated with diabetic neuropathy.