EFFECT OF FATTY-ACID ON THE ACCUMULATION OF THIAMINE DISULFIDE IN RATSKIN

The effect of long chain fatty acid (FA) and its analogs on the accumu lation of thiamine disulfide (TDS) in rat skin using propylene glycol as a vehicle was studied in vitro. Lauric acid (12:0) increased the ac cumulation of TDS in skin, while myristic acid and stearic acid caused a slight decrease in accumulation. Lauryl alcohol and lauric acid met hyl ester did not change the accumulation of TDS in the skin. The rati o of the amount of TDS accumulated in skin to the solubility of TDS in the vehicle increased dependent on the concentration of 12:0 added in the vehicle. It was suggested that the increase in the permeability c oefficient of TDS by 12:0 results from the enhanced transport of TDS f rom the vehicle to skin.