EFFECTS OF 2,5-DIMETHYLPYRAZINE ON PLASMA TESTOSTERONE AND POLYAMINESAND ACID PHOSPHATASE-LEVELS IN THE RAT PROSTATE

The effects of 2,5-dimethylpyrazine (DMP) on plasma testosterone and l evels of polyamines and acid phosphatase in the prostate of rat were s tudied. A high dose of DMP administered once daily for two weeks to ju venile male rats significantly decreased plasma testosterone and level s of polyamines and acid phosphatase in the prostate. These effects we re not obtained by administration to mature male rats, and the inhibit ion was thus recognized to occur during the growth period. These findi ngs suggest that a high dose of DMP inhibits the biosynthesis of polya mines and acid phosphatase in the prostate by decreasing the circulati ng testosterone level.