ENHANCED FLUID INTAKE BY RATS AFTER CAPSAICIN TREATMENT

Citation
Ks. Curtis et Em. Stricker, ENHANCED FLUID INTAKE BY RATS AFTER CAPSAICIN TREATMENT, American journal of physiology. Regulatory, integrative and comparative physiology, 41(2), 1997, pp. 704-709
Citations number
33
Categorie Soggetti
Physiology
ISSN journal
03636119
Volume
41
Issue
2
Year of publication
1997
Pages
704 - 709
Database
ISI
SICI code
0363-6119(1997)41:2<704:EFIBRA>2.0.ZU;2-I
Abstract
These studies examined stimulated fluid intake by rats in which vagall y mediated signals of gastric distension were blunted by systemic trea tment with the neurotoxin capsaicin, as verified by the loss of cholec ystokinin-induced inhibition of feeding. After overnight food deprivat ion, intake of a 10% sucrose solution by capsaicin-treated rats was gr eater than that by control rats. Similarly, capsaicin-treated rats dra nk more water than did control rats when stimulated by plasma hyperosm olality after intraperitoneal administration of hypertonic NaCl or by isosmotic hypovolemia after subcutaneous administration of a hyperonco tic colloidal solution. Finally, during chronic administration of the mineralocorticoid deoxycorticosterone acetate, capsaicin treated rats consumed more concentrated saline than did control rats. In all tests, intakes by capsaicin-treated rats were significantly greater than tho se by control rats within 5-15 min. These results suggest that early s ignals of gastric distension, such as those that occur during normal e pisodes of food, water, or NaCl intake, may modulate ongoing ingestion and that, with the attenuation of such general inhibitory signals, in gestion continues until gastric distension becomes larger and/or later postgastric signals are detected.