T. Uchibayashi et al., EXPERIMENTAL-STUDY OF RADIOFREQUENCY CAPACITIVE HYPERTHERMIA ON TRANSPLANTED TUMOR, International journal of oncology, 4(6), 1994, pp. 1301-1304
The in vivo effects of radiofrequency capacitive hyperthermia combined
with cis-diammine-dichloroplatinum (CDDP) were studied using nude mic
e bearing a subcutaneous graft of KK-47 cells derived from human bladd
er cancer. Tumor growth curve was obtained by measuring the transplant
ed tumor volume for 21 consecutive days after the treatment. After the
treatment, the tumor was removed and examined light-microscopically.
Tumor growth was inhibited for 21 days after chemotherapy, hyperthermi
a, or chemohyperthermia, as compared with the control group. Comparing
the chemohyperthermia group with the other groups, it was found that
tumor reduction rate was greater in the former group than those in oth
er groups tested. With respect to the combined chemohyperthermic treat
ment, hyperthermia significantly enhanced the anti-tumor efficacy of C
DDP.