Cutaneous abscesses are an uncommon manifestation of Acanthamoeba infe
ction. We report a case of a patient with acquired immunodeficiency sy
ndrome who developed multiple cutaneous lesions on bis arms, legs, and
trunk. Skin biopsies revealed cysts and trophozoites of Acanthamoeba
spp with invasion of blood vessel walls associated with tissue necrosi
s. Brain lesions examined at autopsy failed to reveal amoeba and no ot
her foci of amoebic infection were found.