TRANSLOCATION (1222)(P13Q12) AS SOLE KARYOTYPIC ABNORMALITY IN A PATIENT WITH NONLYMPHOCYTIC LEUKEMIA

Authors
VANKESSEL AG STELLINK F VANGAAL J VANDEKLUNDERT W SIEPMAN A OOSTEN HR
Citation
Ag. Vankessel et al., TRANSLOCATION (1222)(P13Q12) AS SOLE KARYOTYPIC ABNORMALITY IN A PATIENT WITH NONLYMPHOCYTIC LEUKEMIA, Cancer genetics and cytogenetics, 72(2), 1994, pp. 105-108
Citations number
20
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
72
Issue
2
Year of publication
1994
Pages
105 - 108
Database
ISI
SICI code
0165-4608(1994)72:2<105:T(ASKA>2.0.ZU;2-O
Abstract
Cytogenetic analysis of unstimulated bone marrow (BM) and peripheral b lood (PB) cells of a patient with clinical features of atypical chroni c myeloid leukemia (CML) showed t(12;22)(p13;q12) as the sole karyotyp ic abnormality. Subsequent fluorescence in situ hybridization (FISH) w ith abl- and bcr-specific cosmids as well as chromosome 12- and 22-spe cific DNA libraries and Southern blot analysis confirmed that in this patient t(12;22) does not constitute a cryptic Ph variant. Recently, a few very similar cases were reported by other investigators. The poss ible significance of this translocation as a new cytogenetic marker fo r nonlymphocytic leukemia is discussed.