ISOLATION OF AN ADHESIN FROM STAPHYLOCOCCUS-AUREUS THAT BINDS LEWIS(A) BLOOD-GROUP ANTIGEN AND ITS RELEVANCE TO SUDDEN-INFANT-DEATH-SYNDROME

Authors
SAADI AT WEIR DM POXTON IR STEWART J ESSERY SD BLACKWELL CC RAZA MW BUSUTTIL A
Citation
At. Saadi et al., ISOLATION OF AN ADHESIN FROM STAPHYLOCOCCUS-AUREUS THAT BINDS LEWIS(A) BLOOD-GROUP ANTIGEN AND ITS RELEVANCE TO SUDDEN-INFANT-DEATH-SYNDROME, FEMS immunology and medical microbiology, 8(4), 1994, pp. 315-320
Citations number
32
Categorie Soggetti
Immunology,Microbiology
Journal title
FEMS immunology and medical microbiology → ACNP
ISSN journal
09288244
Volume
8
Issue
4
Year of publication
1994
Pages
315 - 320
Database
ISI
SICI code
0928-8244(1994)8:4<315:IOAAFS>2.0.ZU;2-F
Abstract
A 67 kDa protein was isolated from cell membrane preparations of Staph ylococcus aureus (NCTC 10655) by affinity adsorption with synthetic Le wis(a) antigen conjugated to Synsorb beads. Pre-treatment of buccal ep ithelial cells expressing Lewis(a) with the purified protein reduced b inding of the staphylococcal strain to a greater extent than the mater ial not bound to the Synsorb beads. The significance of this work is d iscussed with reference to expression of Lewis a antigen in infants an d the proposed role of toxigenic strains of staphylococci in some case s of sudden infant death syndrome.