ALTERATION BY ILOPROST OF THE VASOSPASTIC EFFECTS OF ENDOTHELIN-1 IN RABBIT CEREBRAL VESSELS

Authors
KESKIL IS BAYKANER MK SENCER H ATAOGLU O ILGIT E ERDOGAN B CEVIKER N ERCAN ZS
Citation
Is. Keskil et al., ALTERATION BY ILOPROST OF THE VASOSPASTIC EFFECTS OF ENDOTHELIN-1 IN RABBIT CEREBRAL VESSELS, NeuroReport, 5(9), 1994, pp. 1089-1092
Citations number
25
Categorie Soggetti
Neurosciences
Journal title
NeuroReport → ACNP
ISSN journal
09594965
Volume
5
Issue
9
Year of publication
1994
Pages
1089 - 1092
Database
ISI
SICI code
0959-4965(1994)5:9<1089:ABIOTV>2.0.ZU;2-K
Abstract
THE reversal of endothelin-1 induced cerebral vasospasm with Iloprost was studied in the rabbit. Vasospasm in the basilar artery was evaluat ed by angiography; cerebral ischaemia by 'red-neurone-count' on light microscopy and morphological changes by electron microscopy. A potent antagonistic effect of Iloprost against ET-1 was observed in each of t he parameters measured.