CYTOTOXIC-CELLS BY HYBRIDIZATION IN-SITU AND IMMUNOHISTOCHEMISTRY IN MUSCLE-TISSUE BIOPSIES FOR POLYMYOSITIS AND DERMATOMYOSITIS

Authors
CHERIN P CREVON MC HAUW JJ GALANAUD P HERSON S EMILIE D
Citation
P. Cherin et al., CYTOTOXIC-CELLS BY HYBRIDIZATION IN-SITU AND IMMUNOHISTOCHEMISTRY IN MUSCLE-TISSUE BIOPSIES FOR POLYMYOSITIS AND DERMATOMYOSITIS, La Revue de medecine interne, 14(6), 1993, pp. 493-493
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
Journal title
La Revue de medecine interne → ACNP
ISSN journal
02488663
Volume
14
Issue
6
Year of publication
1993
Pages
493 - 493
Database
ISI
SICI code
0248-8663(1993)14:6<493:CBHIAI>2.0.ZU;2-3
Abstract
Cytotoxic cells can kill target cells by secretion of several protease s, serine esterase B (SE-B), perforin (PF) and protein TIA-1. We analy sed the presence of cytotoxic cells expressing the SE-B and PF genes b y in situ hybridization and expression of TIA-1 by immunohistochimical study from muscular biopsies of 13 patients with inflammatory myopath ies ; compared to those from 11 subjects control. We found expression of PF in 9 patients, SE-B gene in 10 and liberation of TIA-1 in 12 out of the 13 muscular biopsies tested, supporting the role of cytotoxic cells in pathogeny of inflammatory myopathies.