Periventricular leukomalacia (PVL) occurring in relation to the body o
f the lateral ventricle could account for damage to the corticospinal
tracts. However, PVL in this location is relatively rare, and the view
that it causes the diplegia of preterm birth is challenged on the ana
tomical grounds that the corticospinal tracts to the legs are some dis
tance away from the main sites of PVL, which are at the collateral tri
gone and near to the interventricular foramen. If PVL lesions do cause
permanent nerve damage, it is surprising that cortical blindness in d
iplegia is so uncommon. A dying-back neuropathy caused by selective da
mage to corticospinal neurons could be considered as an alternative hy
pothesis to account for the paralysis of diplegia.