DIDEOXY SEQUENCING AND STRUCTURAL-ANALYSIS OF THE RAT INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 GENE

Authors
LACSON R OEHLER D YANG E GOSWAMI R UNTERMAN T
Citation
R. Lacson et al., DIDEOXY SEQUENCING AND STRUCTURAL-ANALYSIS OF THE RAT INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 GENE, Biochimica et biophysica acta, N. Gene structure and expression, 1218(1), 1994, pp. 95-98
Citations number
16
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1218
Issue
1
Year of publication
1994
Pages
95 - 98
Database
ISI
SICI code
0167-4781(1994)1218:1<95:DSASOT>2.0.ZU;2-X
Abstract
Insulin-like growth factor binding protein-1 (IGFBP-1) is an important modulator of IGF bioavailability. To facilitate studies of IGFBP-1 re gulation and function in rodent models, we cloned the rat IGFBP-1 gene and analyzed its structure by dideoxy sequencing. The rat IGFBP-1 gen e is relatively small (similar to 5 kb) and contains 4 exons and 3 int rons, similar to the human IGFBP-1 gene.