EFFICIENT COUPLING OF ALPHA,ALPHA-DIMETHYL AMINO-ACID USING A NEW CHLORO IMIDAZOLIDIUM REAGENT, CIP

Authors
AKAJI K KURIYAMA N KISO Y
Citation
K. Akaji et al., EFFICIENT COUPLING OF ALPHA,ALPHA-DIMETHYL AMINO-ACID USING A NEW CHLORO IMIDAZOLIDIUM REAGENT, CIP, Tetrahedron letters, 35(20), 1994, pp. 3315-3318
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
20
Year of publication
1994
Pages
3315 - 3318
Database
ISI
SICI code
0040-4039(1994)35:20<3315:ECOAAU>2.0.ZU;2-#
Abstract
CIP (2-chloro-1,3-dimethylimidazolidium hexafluorophosphate) was an ef ficient coupling agent for N-alpha-protected alpha-aminoisobutyric aci d (Aib) in the presence of an additive. The reactivity was enhanced ma rkedly by a catalytic amount of additive in the order of HOAt similar to HODhbt>DMAP>HOBt. These couplings occurred without detectable racem ization.