I. Paterson et al., TOWARDS THE SYNTHESIS OF SWINHOLIDE-A AND SCYTOPHYCIN-C - A HIGHLY STEREOCONTROLLED SYNTHESIS OF (-)-PRE-SWINHOLIDE-A, Tetrahedron letters, 35(20), 1994, pp. 3405-3408
The fully protected monomeric unit 19 of the marine macrodiolide, swin
holide A (1), was obtained with >97% ds by a Mukaiyama aldol reaction
between 16 and 5, followed by a boron-mediated reduction to give the s
yn 1,3-diol 18. Deprotection gave (-)-pre-swinholide A (2), the putati
ve biosynthetic precursor of 1.