FLUOROQUINOLONE DISTRIBUTION IN A PHOSPHOLIPID ENVIRONMENT STUDIED BYSPECTROFLUOROMETRY

Authors
MONTERO MT HERNANDEZBORRELL J NAG K KEOUGH KMW
Citation
Mt. Montero et al., FLUOROQUINOLONE DISTRIBUTION IN A PHOSPHOLIPID ENVIRONMENT STUDIED BYSPECTROFLUOROMETRY, Analytica chimica acta, 290(1-2), 1994, pp. 58-64
Citations number
16
Categorie Soggetti
Chemistry Analytical
Journal title
Analytica chimica acta → ACNP
ISSN journal
00032670
Volume
290
Issue
1-2
Year of publication
1994
Pages
58 - 64
Database
ISI
SICI code
0003-2670(1994)290:1-2<58:FDIAPE>2.0.ZU;2-E
Abstract
The intrinsic fluorescence of fluoroquinolones was exploited first to discriminate between fluorophore populations after encapsulation in li posomes, and second to observe by epifluorescence their distribution i n phospholipid monolayers. The affinity of fluoroquinolones for a hydr ophobic environment and especially for phospholipids could help in int erpreting the mechanism of drug uptake in bacteria. Additionally, this will lead to improved encapsulation efficiencies of these drugs in li posomes.