Gd. Lumb et Fw. Sunderman, THE PROBLEM OF LATENCY IN THE DEVELOPMENT OF TUMORS FOLLOWING EXPOSURE TO NICKEL COMPOUNDS, Science of the total environment, 148(2-3), 1994, pp. 185-190
Six previously published animal studies of tumor production have been
reviewed, in order to relate time interval between exposure to nickel
and development of tumor formation. Biopsies at intervals before final
tumor formation, in some of these experiments, were reviewed to defin
e interim changes between exposure and tumor diagnosis. Correlation be
tween rat and human life span was used to suggest a latency of human t
umor expectancy following exposure to nickel.