Because of its volatility and other unique properties, nickel tetracar
bonyl has specialized industrial uses. It is an extremely toxic substa
nce and induces systemic poisoning, with the lungs and brain being esp
ecially susceptible targets. The clinical symptoms and management of p
atients accidentally exposed are reviewed in considerable detail. Alth
ough them is some suggestion that nickel tetracarbonyl is a carcinogen
in animals, the available epidemiologic data do not support such a li
nk in humans. Continual monitoring and long-term follow-up of exposed
workers is recommended.