This paper is centered on two basic statements: i) the birth of new fi
rms is spatially related to location factors endowment and ii) the set
of location factors can support only up to a given number of firms. T
he paper firstly defines the regional ex-ante demand for firms as a fu
nction of location factors set. In the following step a definition of
regional equilibrium stock of firms is given and a static equilibrium
model of new firms birth is built up. In a dynamic disequilibrium mode
l the net birth of firms is a function of two disequilibrium terms: a
sectoral and a regional one. The sectoral disequilibrium depends on th
e industry production structure, the regional disequilibrium is linked
to the adaptation elasticity of location factors set to an exogenous
shock. Finally, a first estimation on Italian data is performed, on th
e basis of which some new lines of analysis are suggested.