THE (G)GAMMA-(A)GAMMA RATIOS IN THE FETAL HEMOGLOBIN OF NEWBORNS OF THE MAN ETHNIC-GROUP AND THEIR GAMMA-GLOBIN GENE ARRANGEMENTS

The (G) gamma:(A) gamma ratios of Hb F were determined in 331 newborn babies of the Man ethnic group in Liaoning Province, P.R. China, using polyacrylamide gel electrophoresis; in 27 cases they were also determ ined by reversed phase high performance liquid chromatography. The res ults showed that a high (G) gamma value (>80%) was present in four cas es (1.21%) and low (G) gamma values (30-48%) in six cases (1.81%); not a single case with the (A) gamma(T) [(A) gamma 75(E19)Ile-->Thr] chai n was found. Gene mapping analysis demonstrated that two babies values with high (G) gamma values had the -(G) gamma-(G) gamma-/-(G) gamma-( A) gamma- (0.60%), and two others the -(G) gamma-(AG)gamma-(A) gamma-/ -(G) gamma-(A) gamma- (0.60%) arrangements. Two of the four babies wit h low (G) gamma values were identified as -(A) gamma-(A) gamma-/-(G) g amma-(A) gamma- (0.60%) and the other two as -(GA)gamma-/-(G) gamma-(A ) gamma- (0.60%). The genotype -(A) gamma-(A) gamma- has not been repo rted before in Chinese.