IN-VITRO RELEASE AND PERMEATION KINETICS OF PENTAZOCINE FROM MATRIX-DISPERSION TYPE TRANSDERMAL DRUG-DELIVERY SYSTEMS

A matrix-dispersion type Transdermal Drug Delivery System (TDS) of Pen tazocine (PZ) was fabricated, using combinations of rate controlling p olymers, namely Eudragits RS100 (RS), RL100 (RL), Ethylcellulose (EC) and Polyvinyl pyrrolidone (PVP), with the objective of examining the e ffects bf formulation variables on drug-permeation profiles. In depth in-vitro drug release and skin-permeation kinetics with three differen t loads, and also the effects of combination of Isopropyl Myristate (I PM), as permeation enhancer, were studied using male albino mice abdom inal skin. The release of PZ over a 12 hour period followed Higuchi ki netics, while in-vitro mice-skin permeation of PZ followed an apparent Zero-order kinetics over a period of 24 hours.