INFECTION OF HUMAN ENDOTHELIAL-CELLS BY RICKETTSIA-RICKETTSII CAUSES A SIGNIFICANT REDUCTION IN THE LEVELS OF KEY ENZYMES INVOLVED IN PROTECTION AGAINST OXIDATIVE INJURY

Authors
DEVAMANOHARAN PS SANTUCCI LA HONG JE TIAN XJ SILVERMAN DJ
Citation
Ps. Devamanoharan et al., INFECTION OF HUMAN ENDOTHELIAL-CELLS BY RICKETTSIA-RICKETTSII CAUSES A SIGNIFICANT REDUCTION IN THE LEVELS OF KEY ENZYMES INVOLVED IN PROTECTION AGAINST OXIDATIVE INJURY, Infection and immunity, 62(6), 1994, pp. 2619-2621
Citations number
17
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
6
Year of publication
1994
Pages
2619 - 2621
Database
ISI
SICI code
0019-9567(1994)62:6<2619:IOHEBR>2.0.ZU;2-W
Abstract
The activities of glucose-6-phosphate dehydrogenase, catalase, and glu tathione peroxidase were significantly decreased in human endothelial cells infected with the obligate intracellular bacterium Rickettsia ri ckettsii, the causative agent of Rocky Mountain spotted fever. This ob servation lends additional support to our hypothesis implicating oxida tive damage in endothelial cell injury caused by this microorganism.