CLONING OF A NONCATALYTIC FORM OF HUMAN TRKB AND DISTRIBUTION OF MESSENGER-RNA FOR TRKB IN HUMAN BRAIN

Authors
ALLEN SJ DAWBARN D ECKFORD SD WILCOCK GK ASHCROFT M COLEBROOK SM FEENEY R MACGOWAN SH
Citation
Sj. Allen et al., CLONING OF A NONCATALYTIC FORM OF HUMAN TRKB AND DISTRIBUTION OF MESSENGER-RNA FOR TRKB IN HUMAN BRAIN, Neuroscience, 60(3), 1994, pp. 825-834
Citations number
42
Categorie Soggetti
Neurosciences
Journal title
Neuroscience → ACNP
ISSN journal
03064522
Volume
60
Issue
3
Year of publication
1994
Pages
825 - 834
Database
ISI
SICI code
0306-4522(1994)60:3<825:COANFO>2.0.ZU;2-7
Abstract
A truncated form of the human trkB gene has been cloned and sequenced. This gene is related to the trk family of tyrosine kinases, the produ cts of which act as receptors for the neurotrophins. Of these, brain-d erived neurotrophic factor and mammalian neurotrophin-4 are the known ligands for the TrkB receptor. Catalytic and non-catalytic (or truncat ed) forms of the trkB gene have been cloned for rat and mouse. In this study, using in situ hybridization, we describe the distribution of t rkB messenger RNA in fetal and adult human brain.