GATING AND CONDUCTANCE PROPERTIES OF A HUMAN DELAYED RECTIFIER K+ CHANNEL EXPRESSED IN FROG OOCYTES

Authors
BENNDORF K KOOPMANN R LORRA C PONGS O
Citation
K. Benndorf et al., GATING AND CONDUCTANCE PROPERTIES OF A HUMAN DELAYED RECTIFIER K+ CHANNEL EXPRESSED IN FROG OOCYTES, Journal of physiology, 477(1), 1994, pp. 1-14
Citations number
34
Categorie Soggetti
Physiology
Journal title
Journal of physiology → ACNP
ISSN journal
00223751
Volume
477
Issue
1
Year of publication
1994
Pages
1 - 14
Database
ISI
SICI code
0022-3751(1994)477:1<1:GACPOA>2.0.ZU;2-M
Abstract
1. The human delayed rectifier K+ channel h-DRK1, a homologue to the D RK1 channel in the rat, was expressed in Xenopus oocytes. Single-chann el currents were measured in micropatches; macroscopic currents were m easured either in macropatches, giant patches, or whole oocytes. 2. Ma croscopic currents activated at -20 mV and more positive. The instanta neous current-voltage relationship rectified outwardly to a higher deg ree than predicted by the Goldman-Hodgkin-Katz equation.