PREPARATION AND REACTIONS OF THE 2,3,5,6-TETRAFLUOROPYRIDYLCOPPER REAGENT

4-Iodotetrafluoropyridine and 4-bromotetrafluoropyridine react readily with acid-washed cadmium or zinc powder in DMF at room temperature to give the 2,3,5,6-tetrafluoropyridylcadmium or 2,3,5,6-tetrafluoropyri dylzinc reagent in quantitative yield. Metathesis of the cadmium or zi nc reagent with CuBr at room temperature gives the stable 2,3,5,6-tetr afluoropyridylcopper reagent. The 2,3,5,6-tetrafluoropyridylcopper rea gent couples with allylic halides, vinyl iodides, aryl iodides and acy l halides to give the corresponding adducts in high yield.