POTENTIAL ANTIMALARIALS .20. MANNICH BASE DERIVATIVES OF 2-[7-CHLOROQUINOLIN-4-YLAMINO AND 7-BROMO(AND OROMETHYL)-1,5-NAPHTHYRIDIN-4-YLAMINO]-4-CHLORO(OR 4-T-BUTYL OR 6-T-BUTYL OR 4-FLUORO) OR 5-FLUORO)PHENOL AND 4(OR UTYL-2-(7-TRIFLUOROMETHYLQUINOLIN-4-YLAMINO)PHENOL

Authors
BAWRLIN GB IRELAND SJ NGUYEN TMT KOTECKA B RIECKMANN KH
Citation
Gb. Bawrlin et al., POTENTIAL ANTIMALARIALS .20. MANNICH BASE DERIVATIVES OF 2-[7-CHLOROQUINOLIN-4-YLAMINO AND 7-BROMO(AND OROMETHYL)-1,5-NAPHTHYRIDIN-4-YLAMINO]-4-CHLORO(OR 4-T-BUTYL OR 6-T-BUTYL OR 4-FLUORO) OR 5-FLUORO)PHENOL AND 4(OR UTYL-2-(7-TRIFLUOROMETHYLQUINOLIN-4-YLAMINO)PHENOL, Australian Journal of Chemistry, 47(6), 1994, pp. 1143-1154
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Australian Journal of Chemistry → ACNP
ISSN journal
00049425
Volume
47
Issue
6
Year of publication
1994
Pages
1143 - 1154
Database
ISI
SICI code
0004-9425(1994)47:6<1143:PA.MBD>2.0.ZU;2-5
Abstract
Syntheses are reported for some mono- and di-Mannich base derivatives of 4-chloro-, 3- or 4-fluoro-, or 2- or 4-t-butyl-substituted 2-(7'-ch loroquinolin-4'-ylamino)phenols and 2-[7'-bromo(and uoromethyl)-1',5'- naphthyridin-4'-ylamino]phenols. In tests against the Fc-27 isolate of Plasmodium falciparum, the most active compound was no)-5-fluoro-4,6- bis(piperidin-1''-ylmethyl)phenol (16) with IC50 12.2 nM.