Multiple subpial transections (MST) were made in language cortex in th
ree patients with medically refractory partial epilepsy. All patients
were mapped with extra-operative stimulation using subdural grids over
the dominant temporal, frontal and parietal convexity. Two patients h
ad anterior temporal lobectomy and MST in posterior language cortex. O
ne patient who had undergone a previous frontal tumour resection had o
nly MST over the frontoparietal convexity, including frontal and parie
tal language areas. Both patients with MST in the posterior language c
ortex had postoperative language dysfunction, which had improved signi
ficantly by 9 months after surgery, The patient with MST in frontopari
etal language areas had improved language functions immediately postop
eratively. The two men with anterior temporal lobectomies and MST are
seizure-free at 1 year follow-up and the woman with fronto-parietal MS
T has had a > 70% reduction in seizure frequency at 1 year follow-up.