SYNTHESIS AND SPECTROSCOPY STUDIES OF COPPER(II) NITRATE OF SULFACETAMIDE DRUG - CRYSTAL-STRUCTURE OF [CU(SULFACETAMIDE)(2)(NO3)(2)] - ANTIBACTERIAL STUDIES

The structural spectroscopic, and thermal properties of a complex of s ulfacetamide (Hsacm) with Cu(II) have been investigated. The complex [ Cu(Hsacm)(2)(NO3)(2)] crystallizes in the monoclinic system, space gro up P2(1)/n. The cell dimensions are a = 7.696(7) Angstrom, b = 8.017(7 ) Angstrom, c = 19.230(10), beta = 110.80(1)degrees, V = 1109(1)Angstr om(3), Z = 2, and D-x = 1.84 g/cm(3). The structure was refined to R = 0.0776. Cu(Hsacm)(2)(NO3)(2) molecules form a long polymeric chain ex tended along the b-axis. The copper(II) coordinated geometry is tetrag onally distorted octahedral with two amino nitrogens from Hsacm and tw o oxygens from nitrate anions in the basal plane and two acetamido oxy gens from neighbor Hsacm molecules in the apical position. Each sulfac etamide, acting as a bidentate ligand, links two Cu(II) ions as a brid ge through the N-amino and the O-acetamido atoms. The complex proved t o possess higher bacteriostatic activity than the corresponding ligand .