HIGH DOSAGES OF GONADOTROPINS ARE ASSOCIATED WITH POOR PREGNANCY OUTCOMES AFTER IN-VITRO FERTILIZATION-EMBRYO TRANSFER

Objective: To compare the pregnancy outcomes during IVF-ET when differ ent dosages of hMG are used after follicular phase suppression with le uprolide acetate (LA). Design: Retrospective chart review. Setting: Ho spital-based IVF-ET program. Patients: From January 1990 to December 1 992, 264 cycles reached ET after LA downregulation and gonadotropin st imulation. Results: Higher doses of gonadotropins, as measured by both average daily dose and total dose per cycle, were associated with low er clinical pregnancy rates. This effect was independent of age, basal FSH level, endometrial thickness, maximal E(2) levels, number of eggs retrieved, and embryos transferred. Conclusion: High dosages of exoge nous gonadotropins are associated with lower pregnancy rates in IVF-ET .