L. Stadtmauer et al., HIGH DOSAGES OF GONADOTROPINS ARE ASSOCIATED WITH POOR PREGNANCY OUTCOMES AFTER IN-VITRO FERTILIZATION-EMBRYO TRANSFER, Fertility and sterility, 61(6), 1994, pp. 1058-1064
Objective: To compare the pregnancy outcomes during IVF-ET when differ
ent dosages of hMG are used after follicular phase suppression with le
uprolide acetate (LA). Design: Retrospective chart review. Setting: Ho
spital-based IVF-ET program. Patients: From January 1990 to December 1
992, 264 cycles reached ET after LA downregulation and gonadotropin st
imulation. Results: Higher doses of gonadotropins, as measured by both
average daily dose and total dose per cycle, were associated with low
er clinical pregnancy rates. This effect was independent of age, basal
FSH level, endometrial thickness, maximal E(2) levels, number of eggs
retrieved, and embryos transferred. Conclusion: High dosages of exoge
nous gonadotropins are associated with lower pregnancy rates in IVF-ET
.