The infrared and Laser Raman spectra of procaine with free basis in th
e solid state were obtained. The characteristic vibrational frequencie
s of their different modes were identified and assigned from isotope s
hifts and theoretical calculations. An infrared study in the liquid ph
ase was also carried out. The corresponding rotation and inversion bar
riers in p-amino group were computed by means of different optimizatio
n procedures.