SYNTHESES AND BIOLOGICAL-ACTIVITY OF PROPOXY-1,7,7-TRIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE AND ITS DERIVATIVES

Authors
KHADILKAR BM SARAF MN PUJARI AA
Citation
Bm. Khadilkar et al., SYNTHESES AND BIOLOGICAL-ACTIVITY OF PROPOXY-1,7,7-TRIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE AND ITS DERIVATIVES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 33(6), 1994, pp. 600-602
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
33
Issue
6
Year of publication
1994
Pages
600 - 602
Database
ISI
SICI code
0376-4699(1994)33:6<600:SABOP>2.0.ZU;2-Q
Abstract
Potassium salts of the camphor oxime (1) and camphor quinone-2-oxime ( 7) on reaction with epichlorhydrin followed by treatment with HCl give 2-[N-(3-chloro-2-hydroxypropoxy)imino]-1, 7, 7-trimethylbicyclo[2.2.1 ]heptane (3) and its 3-oxo derivative (9) respectively. The halo-hydri ns of 3 and 9 on condensation with 1-arylpiperazines in acetonitrile y ield -(4-aryl-1-piperazinyl)-2-hydroxypropoxy]imino}-1, 7, 7-trimethyl bicyclo[2.2.1]-heptanes (4) and their 3-oxo derivatives (10), respecti vely. The compounds 4 and 10 show positive ionotropic effect but do no t show the expected beta-adrenergic blocking activity.