SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW SULFONAMIDES FROM 3,5-DIHALO-4-ALKOXYANILINES, 3-HALO-4-ALKOXYANILINES AND 3,4,5-TRIHALOANILINES

Condensation of p-acetamidobenzenesulphonyl chloride (1) with halo-alk oxyanilines (2) in pyridine gives the lo-substituted-4-alkoxyphenyl)-p -acetamido-benzene sulphonamides (3) which on hydrolysis with aq. sodi um hydroxide gives N-(halo-substituted-4-alkoxyphenyl)-p-aminobenzene sulphonamides (4). The structure of these compounds have been elucidat ed on the basis of their elemental analyses and spectral data. These c ompounds exhibit moderate to good antibacterial and antitubercular act ivities.