IN SEARCH OF NEW NEUROMUSCULAR BLOCKING-DRUGS WITH QUICK ONSET AND SHORT-DURATION OF EFFECT

In experiments using cats the neuromuscular blocking effect of bis-tri methylammonium derivatives having a non-depolarizing mode of action ha d an onset of action shorter than that of their triethylammonium analo gs. The difference in equieffective doses of neuromuscular blocking ag ents administered intravenously or intraarterially was less in the cas e of compounds with rigid molecules than that with flexible molecules. Results indicate that a more considerable portion of flexible substan ce absorbs on the 'site of loss' in blood vessels than for rigid compo unds. This suggests that rigid molecules promote a faster achievement of effective concentration of a neuromuscular blocking agent at synaps es. Proceeding from these data a bis-trimethylammonium derivative with a rigid molecule, IEM-1213, was synthesized and studied in cats.