Cj. Gardner et al., THE EFFECTS OF GR79236 ON PLASMA FATTY-ACID CONCENTRATIONS, HEART-RATE AND BLOOD-PRESSURE IN THE CONSCIOUS RAT, European journal of pharmacology, 257(1-2), 1994, pp. 117-121
GR79236 (N-[(1S,trans)-2-hydroxycyclopentyl]adenosine) is orally activ
e adenosine A(1) receptor agonist, which decreases plasma non-esterifi
ed fatty acid levels in fasted rats. This study has quantified the eff
ects of GR79236 on plasma non-esterified fatty acid levels, blood pres
sure and heart rate in conscious rats. Blood pressure and heart rate w
ere continuously recorded in rats for 30 min before and 1 h after oral
dosing with GR79236 (0.03-3 mg/kg) or vehicle. Plasma non-esterified
fatty acid concentrations were determined in blood sampled before and
1 h after dosing. GR79236 produced dose-related reductions in plasma n
on-esterified fatty acid concentrations, with an almost maximal effect
(63.2%) occurring after 1 mg/kg. This dose induced a small but signif
icant decrease in heart rate (12.0%), and a non-significant decrease i
n mean brood pressure (6.3%). Thus, in the conscious rat, GR79236 can
exert profound antilipolytic effects with minimal effects on blood pre
ssure and heart rate.