CGS-21680 ANTAGONIZES MOTOR HYPERACTIVITY IN A RAT MODEL OF HUNTINGTONS-DISEASE

Authors
POPOLI P PEZZOLA A REGGIO R CAPORALI MG DECAROLIS AS
Citation
P. Popoli et al., CGS-21680 ANTAGONIZES MOTOR HYPERACTIVITY IN A RAT MODEL OF HUNTINGTONS-DISEASE, European journal of pharmacology, 257(1-2), 1994, pp. 180000005-180000006
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
257
Issue
1-2
Year of publication
1994
Pages
180000005 - 180000006
Database
ISI
SICI code
0014-2999(1994)257:1-2<180000005:CAMHIA>2.0.ZU;2-V
Abstract
The influence of CGS 21680 yl)phenethylamino]-5'-N-ethylcarboxamido-ad enosine A(2) receptor agonist, was tested in an animal model of Huntin gton's disease. Male Wistar rats received bilateral intrastriatal inje ctions of quinolinic acid and then, I and 2 weeks later, they were tre ated with intrastriatal CGS 21680 (3 mu g/2 mu l) or saline. While qui nolinic acid-lesioned rats not treated with CGS 21680 showed the typic al motor hyperresponsiveness to d-amphetamine (1 mg/kg i.p.), the intr astriatal injection of CGS 21680 completely prevented this effect.