PROTECTION OF NEUROLOGICAL FUNCTION IN STROKE MODELS AND NEUROPROTECTIVE PROPERTIES OF LUBELUZOLE

Authors
Citation
M. Deryck, PROTECTION OF NEUROLOGICAL FUNCTION IN STROKE MODELS AND NEUROPROTECTIVE PROPERTIES OF LUBELUZOLE, Cerebrovascular diseases, 7, 1997, pp. 18-30
Citations number
43
Categorie Soggetti
Clinical Neurology","Peripheal Vascular Diseas
Journal title
ISSN journal
10159770
Volume
7
Year of publication
1997
Supplement
2
Pages
18 - 30
Database
ISI
SICI code
1015-9770(1997)7:<18:PONFIS>2.0.ZU;2-J
Abstract
Lubeluzole, the S-isomer of a novel difluorobenzothiazole, is a neurop rotective compound aimed at the treatment of acute ischaemic stroke. I n a photochemical stroke model in rats, in which a neurological test w as designed that is also relevant to other stroke models, intravenous posttreatment with lubeluzole stereoselectively rescues sensorimotor f unction (time window of 6 h) and reduces infarct size. Posttreatment w ith lubeluzole also reduces infarct size after middle cerebral artery occlusion in rats, attenuates delayed neuronal death after global isch aemia, and may also act on mechanisms of cerebral oedema. The compound normalizes peri-infarct neuronal excitability and blocks the rise of peri-infarct extracellular concentration of glutamate. Lubeluzole down regulates the nitric oxide synthase (NOS) pathway leading to neurotoxi city and neuronal death. NOS pathway modulation may contribute to the neuroprotective properties of lubeluzole.