RECENT ADVANCES ON CYCLINS, CDKS AND CDK INHIBITORS

Authors
MARTINCASTELLANOS C MORENO S
Citation
C. Martincastellanos et S. Moreno, RECENT ADVANCES ON CYCLINS, CDKS AND CDK INHIBITORS, Trends in cell biology, 7(3), 1997, pp. 95-98
Citations number
46
Categorie Soggetti
Cell Biology
Journal title
Trends in cell biology → ACNP
ISSN journal
09628924
Volume
7
Issue
3
Year of publication
1997
Pages
95 - 98
Database
ISI
SICI code
0962-8924(1997)7:3<95:RAOCCA>2.0.ZU;2-X
Abstract
In eukaryotes, cell division is controlled by cyclin-dependent kinases (CDKs). Here we summarize a few new developments on the regulation of the cell cycle by CDK-cyclin complexes. We have focused on three aspe cts in which there has been recent progress: the structural analysis o f these complexes, the phenotypes of mice carrying knockouts of CDK in hibitors and the role of proteolysis in the regulation of the cell cyc le.