SYNTHESIS OF TRANSITION-STATE INHIBITORS FOR N-RIBOSIDE HYDROLASES AND TRANSFERASES

Authors
FURNEAUX RH LIMBERG G TYLER PC SCHRAMM VL
Citation
Rh. Furneaux et al., SYNTHESIS OF TRANSITION-STATE INHIBITORS FOR N-RIBOSIDE HYDROLASES AND TRANSFERASES, Tetrahedron, 53(8), 1997, pp. 2915-2930
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
8
Year of publication
1997
Pages
2915 - 2930
Database
ISI
SICI code
0040-4020(1997)53:8<2915:SOTIFN>2.0.ZU;2-4
Abstract
A number of 1,4-dideoxy-1,4-imino-1-(S)-(substituted phenyl)-D-ribitol s bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-p yridyl analogue have been synthesized. The key step is the condensatio n of aryllithium or aryl Grignard reagents with the imine 3; derived f rom the protected 1,4-dideoxy-1,4-imino-D-ribitol 4. (C) 1997 Elsevier Science Ltd.