GADOTERIDOL DOSE DEPENDENCE IN MR-IMAGING OF A LIVER-ABSCESS MODEL

A necrotic liver abscess model was studied with magnetic resonance (MR ) imaging at 1.5 T before and after intravenous administration of gado teridol at doses of 0.1, 0.25, and 0.5 mmol/kg in 24 rabbits. Enhancem ent characteristics and lesion delineation were assessed with both bre ath-hold and non-breath-hold imaging techniques. Lesion delineation. a s assessed both by signal intensity measurements and evaluations by tw o image readers blinded to imaging technique. was greatest on high-dos e (0.5 mmol/kg) breath-hold images. Lesion rim enhancement was seen co nsistently only on postcontrast images obtained at a dose of 0.5 mmol/ kg and progressed with time after injection of contrast material.