THE TOTAL SYNTHESIS OF THE NATURAL PRODUCT ENDOTHELIN-CONVERTING ENZYME (ECE) INHIBITOR, WS75624-B

Authors
PATT WC MASSA MA
Citation
Wc. Patt et Ma. Massa, THE TOTAL SYNTHESIS OF THE NATURAL PRODUCT ENDOTHELIN-CONVERTING ENZYME (ECE) INHIBITOR, WS75624-B, Tetrahedron letters, 38(8), 1997, pp. 1297-1300
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
8
Year of publication
1997
Pages
1297 - 1300
Database
ISI
SICI code
0040-4039(1997)38:8<1297:TTSOTN>2.0.ZU;2-B
Abstract
The first total synthesis of WS75624 B, 1, an endothelin converting en zyme inhibitor produced in a fermentation broth of Saccharothrix sp. N o. 75624 is reported herein. WS75624 B is synthesized in 14 steps from commercially available kojic acid, 2. The synthetic methodology allow s for facile substitution at multiple sites on the molecule. (C) 1997 Elsevier Science Ltd.