Wc. Patt et Ma. Massa, THE TOTAL SYNTHESIS OF THE NATURAL PRODUCT ENDOTHELIN-CONVERTING ENZYME (ECE) INHIBITOR, WS75624-B, Tetrahedron letters, 38(8), 1997, pp. 1297-1300
The first total synthesis of WS75624 B, 1, an endothelin converting en
zyme inhibitor produced in a fermentation broth of Saccharothrix sp. N
o. 75624 is reported herein. WS75624 B is synthesized in 14 steps from
commercially available kojic acid, 2. The synthetic methodology allow
s for facile substitution at multiple sites on the molecule. (C) 1997
Elsevier Science Ltd.