APPLICATION OF CHIRAL (E)-CROTYLSILANES IN SYNTHESIS - THE ASYMMETRIC-SYNTHESIS OF THE C19-C34 SPIROKETAL FRAGMENT OF RUTAMYCIN-B

Authors
JAIN NF PANEK JS
Citation
Nf. Jain et Js. Panek, APPLICATION OF CHIRAL (E)-CROTYLSILANES IN SYNTHESIS - THE ASYMMETRIC-SYNTHESIS OF THE C19-C34 SPIROKETAL FRAGMENT OF RUTAMYCIN-B, Tetrahedron letters, 38(8), 1997, pp. 1349-1352
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
8
Year of publication
1997
Pages
1349 - 1352
Database
ISI
SICI code
0040-4039(1997)38:8<1349:AOC(IS>2.0.ZU;2-X
Abstract
The asymmetric synthesis of the spiroketal fragment of rutamycin B is reported employing allylsilane bond construction methodology for the i ntroduction of five of the eight stereogenic centers. In this paper, t he construction of the C19-C28 and C29-C34 fragments as well as their coupling through an alkylation reaction of a lithiated N,N-dimethylhyd razone are described. (C) 1997 Published by Elsevier Science Ltd.