A MULTIGRAM, STEREOSELECTIVE SYNTHESIS OF D-[C-13(5)]RIBOSE FROM D-[C-13(6)]GLUCOSE AND ITS CONVERSION INTO [C-13(5)]NUCLEOSIDES

Authors
AGROFOGLIO LA JACQUINET JC LANCELOT G
Citation
La. Agrofoglio et al., A MULTIGRAM, STEREOSELECTIVE SYNTHESIS OF D-[C-13(5)]RIBOSE FROM D-[C-13(6)]GLUCOSE AND ITS CONVERSION INTO [C-13(5)]NUCLEOSIDES, Tetrahedron letters, 38(8), 1997, pp. 1411-1412
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
8
Year of publication
1997
Pages
1411 - 1412
Database
ISI
SICI code
0040-4039(1997)38:8<1411:AMSSOD>2.0.ZU;2-S
Abstract
The preparation of C-13-labeled ribonucleosides starting from D-[C-13( 6)]glucose in 45% overall yield is described. The key of this short sy nthetic way is the dehomologation of di-O-isopropylidene hexofuranose 2 with periodic acid and NaBH4 that afforded stereoselectively the lab eled ribofuranose derivative 3 in high yield. (C) 1997 Elsevier Scienc e Ltd.