STEREOSELECTIVITY IN THE PETERSON REACTION - APPLICATION TO THE SYNTHESIS OF BRL-49467

Authors
BELL D CROWE EA DIXON NJ GEEN GR MANN IS SHIPTON MR
Citation
D. Bell et al., STEREOSELECTIVITY IN THE PETERSON REACTION - APPLICATION TO THE SYNTHESIS OF BRL-49467, Tetrahedron, 50(22), 1994, pp. 6643-6652
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
22
Year of publication
1994
Pages
6643 - 6652
Database
ISI
SICI code
0040-4020(1994)50:22<6643:SITPR->2.0.ZU;2-G
Abstract
The E:Z selectivity in the introduction of the tri-substituted double bond in BRL 49467 could be controlled by the choice of base and silyl group used in a Peterson olefination reaction. The method allowing opt imum E-selectivity was developed such that it could be scaled up to 10 0mmol.