ACTIVITY OF SUPEROXIDE-DISMUTASE AND ITS ISOENZYMIC SPECTRA IN PERIPHERAL-BLOOD IMMUNOCOMPETENT CELLS IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND RHEUMATOID-ARTHRITIS
Gp. Matveikov et al., ACTIVITY OF SUPEROXIDE-DISMUTASE AND ITS ISOENZYMIC SPECTRA IN PERIPHERAL-BLOOD IMMUNOCOMPETENT CELLS IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND RHEUMATOID-ARTHRITIS, Terapevticeskij arhiv, 66(4), 1994, pp. 57-61
General activity of superoxide dismutase (SOD) and its isoenzymic spec
trum in lymphocytes and neutrophils were studied in the peripheral blo
od from 63 SLP and 85 RA patients. A significant decline in SOD activi
ty and qualitative shifts in SOD isoenzymic spectrum were found in bot
h cell groups. The differences were specific for lymphocytes and neutr
ophils. SOD isoenzymic aberrations proved significant in minimal activ
ity of SLP and RA and go in the same direction in both the diseases. G
eneral SOD activity and its isoenzymic composition can serve sensitive
indications of immunocompetent cell function both in SLP and RA and o
f the need in antioxidants inclusion into combined treatment of both t
he diseases.